Eric Dane, best known for his role as Cal Jacobs, the father of Nate Jacobs (played by Jacob Elordi) in Euphoria, as well as his longtime role on Grey’s Anatomy, has announced that he has been diagnosed with ALS. The 52-year-old actor shared the news in an interview with People magazine.
“I feel fortunate to still be able to work and am looking forward to returning to the set of Euphoria next week,” Dane said. “I kindly ask that you respect my family’s and my privacy during this time.”
But what exactly is ALS? Amyotrophic Lateral Sclerosis, gained global attention through the Ice Bucket Challenge in 2014, which raised millions for ALS research and greatly increased public awareness.
It is also known as Lou Gehrig’s disease, is a progressive neurodegenerative disorder that affects the nerve cells (neurons) responsible for controlling voluntary muscles. Over time, it causes these neurons to degenerate and die, leading to muscle weakness, paralysis, and ultimately the loss of the ability to speak, move, eat, and breathe.
How ALS Affects the Body
The disease attacks motor neurons—nerve cells in the brain and spinal cord that communicate with muscles. As these motor neurons die, the brain can no longer send signals to the muscles, which begin to waste away due to lack of use (a process called atrophy).
Unlike other conditions, this disease typically does not affect a person’s cognitive abilities, meaning memory and reasoning often remain intact even as the body deteriorates. However, in a minority of cases, patients may experience cognitive or behavioral changes.
Early Symptoms
According to the National Institute of Neurological Disorders and Stroke (NINDS) and the ALS Association, early symptoms of Amyotrophic Lateral Sclerosis may include:
- Muscle weakness, especially in the arms or legs
- Difficulty speaking or slurred speech
- Muscle cramps or twitching (fasciculations)
- Trouble swallowing or breathing
- Poor coordination or frequent tripping
These symptoms can begin subtly and are often overlooked or mistaken for other conditions.
What Causes ALS?
The exact cause of ALS is still unknown, but scientists believe it may result from a combination of genetic and environmental factors. There are two main types:
- Sporadic ALS (about 90–95% of cases): Occurs randomly without a family history.
- Familial ALS (about 5–10% of cases): Inherited through genetic mutations.
Some theories suggest that oxidative stress, glutamate toxicity, and immune system dysfunction may contribute to neuron damage, but more research is needed.
Is There a Cure?
Currently, there is no cure for ALS, but there are treatments that can help manage symptoms and potentially slow disease progression.
- Riluzole (Rilutek): The first drug approved by the FDA for ALS. It may slow the progression slightly.
- Edaravone (Radicava): May reduce the decline in physical function in some patients.
- Physical and occupational therapy: Help maintain mobility and independence.
- Speech therapy and assistive devices: Support communication as the disease progresses.
Multidisciplinary care, including respiratory and nutritional support, plays a key role in improving quality of life.
Living With ALS
ALS is a life-altering diagnosis, but many people continue to live meaningful, active lives for years after their symptoms begin. Support from family, caregivers, and ALS organizations can make a tremendous difference.
According to the Mayo Clinic and the Centers for Disease Control and Prevention (CDC), the average life expectancy after diagnosis is about 2 to 5 years, although some people live much longer—famous physicist Stephen Hawking lived with ALS for over 50 years.
ALS is a complex and devastating disease, but research is ongoing, and advances in care continue to improve the lives of those affected. If you or a loved one are experiencing symptoms or need support, reach out to a healthcare provider or an ALS organization for guidance.
USA
ES
MX
CO
CH
PA
ARG
CR
GUA
EC
RD
